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With the use of the ASOs to target the SCN1A NAT, one study was effectively able to rescue the sense SCN1A gene expression, ameliorate neuronal excitability and seizures in a mouse model of DSan effect that almost entirely recapitulates the rescued phenotypes observed via CRISPRa treatment [74, 75]

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Ionization (or deionization) within a proteins structure can have a significant effect on the overall conformation of the protein and, since structure is related to function, a major impact on the activity of a protein

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